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button:disabled{opacity:.35;cursor:default}.roi-switch{position:relative;display:flex;align-items:center;justify-content:space-between;width:100%;min-height:calc(var(--control-height) + 8px);margin:calc(7px * var(--density)) 0 calc(3px * var(--density));padding:3px;border:1px solid var(--line);border-radius:var(--radius-md);background:var(--page-bg);color:var(--muted);isolation:isolate}.roi-switch:before{content:"";position:absolute;inset:3px;border-radius:var(--radius-sm);background:var(--accent-soft);opacity:0;transition:opacity .18s;z-index:-1}.roi-switch>span{display:flex;align-items:center;min-height:var(--control-height);padding:calc(4px * var(--density)) 6px;font-size:var(--text-base);line-height:1.2}.roi-switch i{position:relative;flex:none;width:34px;height:18px;margin-right:6px;border-radius:10px;background:var(--track)}.roi-switch i:after{content:"";position:absolute;top:3px;left:3px;width:12px;height:12px;border-radius:50%;background:var(--muted);transition:transform .18s var(--panel-ease),background-color .18s}.roi-switch[aria-checked=true]{color:var(--accent)}.roi-switch[aria-checked=true]:before{opacity:1}.roi-switch[aria-checked=true] i{background:var(--accent)}.roi-switch[aria-checked=true] i:after{transform:translate(16px);background:var(--selection-ink)}.roi-opacity{display:grid;min-height:0;grid-template-columns:auto minmax(0,1fr) 36px;align-items:center;gap:9px;padding:0 10px;color:var(--muted);font-size:var(--text-sm)}.roi-opacity output{text-align:right}.legend-item>span{min-width:0;white-space:normal;overflow-wrap:anywhere;line-height:1.35}.clone-note{display:block;margin-top:calc(2px * var(--density));color:var(--muted);font-size:11px;font-weight:400;line-height:1.25;white-space:normal}.layer-control.has-subtitle{row-gap:0;padding-bottom:calc(5px * var(--density))}.layer-control>.clone-note{grid-column:1 / -1;margin:calc(-3px * var(--density)) 0 0 24px}.tissue-tooltip{position:fixed;z-index:40;max-width:min(260px,calc(100vw - 16px));padding:6px 9px;border:1px solid var(--line);border-radius:var(--radius-sm);background:var(--surface);color:var(--ink);font-size:var(--text-base);font-weight:600;box-shadow:0 3px 12px #0003;pointer-events:none}.hover-title{display:block}.hover-section+.hover-section,.hover-title:not([hidden])+.hover-section{margin-top:calc(7px * var(--density));padding-top:calc(6px * var(--density));border-top:1px solid var(--line)}.hover-heading{display:block;margin-bottom:3px;color:var(--muted);font-size:10px;font-weight:400}.hover-value{display:block;white-space:pre-line}.hover-mutations .hover-section{margin-top:calc(5px * var(--density));padding-top:0;border-top:0}@media(prefers-reduced-motion:reduce){.coloring-thumb{transition:none}}input[type=range]{width:100%;height:var(--range-height);margin:0;padding:0;appearance:none;background:linear-gradient(to right,var(--accent) 0 var(--fill),var(--track) var(--fill) 100%) center / 100% 4px no-repeat;cursor:ew-resize}input[type=range]::-webkit-slider-runnable-track{height:4px;border-radius:var(--radius-sm);background:transparent}input[type=range]::-webkit-slider-thumb{width:14px;height:14px;margin-top:-5px;border:2px solid var(--surface);border-radius:50%;appearance:none;background:var(--accent)}input[type=range]::-moz-range-track{height:4px;border-radius:var(--radius-sm);background:transparent}input[type=range]::-moz-range-thumb{width:10px;height:10px;border:2px solid var(--surface);border-radius:50%;background:var(--accent)}input[type=range]:hover::-webkit-slider-thumb{background:var(--accent)}input[type=range]:hover::-moz-range-thumb{background:var(--accent)}.orientation-body{display:grid;grid-template-columns:var(--orientation-size) minmax(0,1fr);align-items:center;gap:0 8px}.orientation-body canvas{display:block;width:var(--orientation-size);height:var(--orientation-size)}.orientation-readout{display:grid;gap:calc(7px * var(--density))}.orientation-readout>div{display:flex;justify-content:space-between;gap:8px;font-size:var(--text-sm)}.orientation-readout dt{color:var(--muted)}.rotation-header{display:flex;align-items:center;gap:10px}.rotation-disclosure{flex:1;min-height:30px;padding:0;text-align:left}.rotation-disclosure:hover{color:var(--accent)}.rotation-play{flex:none;width:34px;height:34px;padding:0;border-radius:var(--radius-md);color:var(--accent);background:var(--accent-soft);font-size:var(--text-sm)}.rotation-play:hover,.rotation-play[aria-pressed=true]{color:var(--selection-ink);background:var(--accent)}.rotation-speed{display:grid;grid-template-columns:1fr auto;margin-top:calc(4px * var(--density));color:var(--muted);font-size:var(--text-sm)}.rotation-speed input{grid-column:1 / -1;height:var(--range-height);background:linear-gradient(to right,var(--track) 0 var(--fill-start),var(--accent) var(--fill-start) var(--fill-end),var(--track) var(--fill-end) 100%) center / 100% 4px no-repeat}@media(pointer:coarse){.collapse-display,.rotation-play{width:30px;height:30px;padding:0}.segmented-control button,.text-button,.layer-group-toggle{min-height:30px}.layer-control>label{min-height:var(--control-height)}}